Volume : V, Issue : V, May - 2015
Protective impact of Chelerythrine and DADS against chemically induced hepatocarcinoma
Soumosish Paul, Deblina Misra, Dipanwita Sengupta, Avik Sarkar, Kaustav Dutta Chowdhury, Pradip Kumar Sur, Gobinda Chandra Sadhukhan
Abstract :
Study was performed to explore the efficacy of chelerythrine and DADS in combination against P–DAB  and PB induced hepatocellular carcinoma in mice. Five week aged 100 mice were used for the experimental purpose. Animals were divided into five different groups either of sex and each set contained 10 mice. PDAB in combination with PB were administered to develop hepatocarcinoma. 5mg/kg body weight Chelerythrine and  100mg/kg body weight DADS were used as drug in single and as well as in combination to find out their efficacy in  the protection of liver tissue against carcinogenic exposure. After 120 days of consecutive experiment different biochemical parameters such as ALT, AST, ALKP, GGT and histopathological tissue analysis were performed. Toxicity analysis was conducted by determining the TBARS content in control animal after drug treatment with stipulated dose and  time. Our obsevation revealed that chelerythrine and DADS in combination successfully restored the activities of enzymatic biomarkers and histopathological liver tissue structure similar to control mice.
Keywords :
Article:
Download PDF
DOI : 10.36106/ijar
Cite This Article:
Soumosish Paul, Deblina Misra, Dipanwita Sengupta, Avik Sarkar, Kaustav Dutta Chowdhury, Pradip Kumar Sur, Gobinda Chandra Sadhukhan Protective impact of Chelerythrine and DADS against chemically induced hepatocarcinoma Indian Journal of Applied Research, Vol.5, Issue : 5 May 2015
Number of Downloads : 1128
Soumosish Paul, Deblina Misra, Dipanwita Sengupta, Avik Sarkar, Kaustav Dutta Chowdhury, Pradip Kumar Sur, Gobinda Chandra Sadhukhan Protective impact of Chelerythrine and DADS against chemically induced hepatocarcinoma Indian Journal of Applied Research, Vol.5, Issue : 5 May 2015
Our Other Journals...
-
International Journal of
Scientific Research Visit Website -
PARIPEX Indian Journal
of Research Visit Website -
Global Journal for
Research Analysis Visit Website