Volume : VI, Issue : VII, July - 2016
PROSPECTIVE RANDOMIZED STUDY TO COMPARE CLONIDINE AND DEXMEDETOMIDINE FOR SEDATION IN MECHANICALLY VENTILATED PATIENTS
Dr. Shaheer Ahmed Siddiqui, Dr. Anil Gupta, Dr. Amit Dahiya, Dr. Meenaxi Sharma
Abstract :
BACKGROUND: This prospective, randomized study was undertaken to compare Clonidine and Dexmedetomidine for sedation in mechanically ventilated patients. Materials and Methods: The patients were divided into two groups. Group A (n=40) patients received dexmedetomidine infusion started as a loading dose of 0.7mcg/kg over a period of 10 mins followed by maintenance of 0.2 Mcg/kg/hr with dosage titration up to 0.7mcg/ kg/hr. Group B (n=40) patients received clonidine infusion Sedation will be started with boluses in accordance with patient’s body weight 1mcg/kg/hr of clonidine with titration being achieved up to 2mcg/kg/hr with dosage increments to achieve a score of 4 in SAS. The level of consciousness will be evaluated using Riker Sedation–Agitation Scale. RESULTS: More patients in Group A were found to achieve the target sedation level (Mean RSAS–4 and 80.67% patients) than Group B (Mean RSAS– 4.25, 70% patients). The heart rate was found to be significantly lower in Group B than in Group A from 14 hours to 48 hours. The decrease in heart rate was also higher in Group B than Group A. The baseline hemodynamic parameters were comparable in both groups. The Mean Arterial Pressure was found to be significantly lower in Group B than Group A from 14 hours to 48 hours of the study. Hypotension occurred in 2 of the 40 patients in Group A (5%) and 14 of the 40 patients in Group B (35%). Conclusion: Dexmedetomidine is better drug in comparison to clonidine, as it provided better quality of sedation and hemodynamic stability
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DOI : 10.36106/ijar
Cite This Article:
DR. SHAHEER AHMED SIDDIQUI, DR. ANIL GUPTA, DR. AMIT DAHIYA, DR. MEENAXI SHARMA PROSPECTIVE RANDOMIZED STUDY TO COMPARE CLONIDINE AND DEXMEDETOMIDINE FOR SEDATION IN MECHANICALLY VENTILATED PATIENTS Indian Journal of Applied Research, Vol.6, Issue : 7 JULY 2016
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DR. SHAHEER AHMED SIDDIQUI, DR. ANIL GUPTA, DR. AMIT DAHIYA, DR. MEENAXI SHARMA PROSPECTIVE RANDOMIZED STUDY TO COMPARE CLONIDINE AND DEXMEDETOMIDINE FOR SEDATION IN MECHANICALLY VENTILATED PATIENTS Indian Journal of Applied Research, Vol.6, Issue : 7 JULY 2016
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