Volume : IV, Issue : V, May - 2014

Prevalence of MDR Strains in the Dumping Region Near Vellar Estuary

Pingal Kumari, A. Divya, Arun Kumar, S. Thirugnanasambandan Somasundaram

Abstract :

Antibiotics and their metabolites are discharged in various amounts into the environment as a result of indis –criminate use of those organic compounds in medical, veterinary, agriculture, animal husbandry and aqua –culture practices. The present study revealed that the microbial community of the municipal waste has wide incidence of antibiotic resistance strains. High incidences of resistance to bacitracin, penicillin and tetracycline whereas most sensitivity to chloramphenicol were noticed from the isolated bacterial strains in this study. Most virulence factors are either found on the bacterial cell surface or secreted into their immediate environment. Secreted/Extracellular proteins are of particular importance for vaccine development because they are often immunogenic and have the potential to be recognized early in infection. In this study, different strains showed varied concentrations of extracellular protein levels with increasing concentrations of ampicillin such as50,100,200, and 300μg/100ml. In all the cases, the resistant strains yielded higher percent age of protein whereas the control strains (without ampicillin) found to produce lesser concentration of protein. It can be concluded that the concentration of secreted proteins is directly proportional to the increasing concentration of antibiotic. The higher protein content of PDS2provides possible indication of increased production of protein like metabolites. There is thus a need to know the kind of proteins expressed by resistant strains so as to provide a basis for developing an interference. Further work is being done to characterize the proteins and to investigate their potential for use as vaccine target through antigenicity tests

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Pingal Kumari, A. Divya, Arun Kumar, Thirugnanasambandan Somasundaram Prevalence of MDR Strains in the Dumping Region Near Vellar Estuary Indian Journal of Applied Research, Volume.4, Issue.5, May-2014

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