Novel Metal–based Pharmacologically Dynamic Agents  of Transition Metal(II) Complexes: Designing, Synthesis,  Structural Elucidation, Efficient Nuclease Activity, In Vitro  Antibacterial and In Vitro Antioxidant Assay

Ekamparam Akila; Markandan Usharani; Rangappan Rajavel

Volume : III, Issue : V, May - 2013

Novel Metal–based Pharmacologically Dynamic Agents of Transition Metal(II) Complexes: Designing, Synthesis, Structural Elucidation, Efficient Nuclease Activity, In Vitro Antibacterial and In Vitro Antioxidant Assay

Ekamparam Akila, Markandan Usharani, Rangappan Rajavel

Abstract :

A new tetradentate Schiff base metal(II) complexes [Cu2(C52H34N4O4)], [Ni2(C52H34N4O4)] and [VO2(C52H34N4O4)] derived from Schiff base H2L(L= 4,4′– Bis– [2–(2–hydroxy–phenylimino)–1,2–diphenyl–ethylideneamino]–biphenyl–3,3′–diol, 1:2:2 condensation of 3, 3′–dihydroxybenzidine, Benzil and 2–aminophenol) are reported herein and have been characterized by various physico–chemical techniques like elemental analyses, IR, UV–visible, 1H NMR and ESR as well as magnetic. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pUC18DNA in the presence of H2O2. The Schiff bases and their complexes have been screened for their antibacterial activity against four bacterial strains (Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Klebsilla pneumonia) by disc diffusion method. Additionally, the Cu(II) complex exhibited potential antioxidant properties in in vitro studies.