NOVEL COMPLEXES DERIVED FROM SOME LANTHANONS AND SOME TRANSITION METALS IONS WITH CARBOCYSTEINE AS PHARMACEUTICAL LIGAND

N. Abdel-Ghany; Adel S. Orabi; N.B. El-Assy; Sawssan M.Abuel-Hassan

Volume : III, Issue : XII, December - 2013

NOVEL COMPLEXES DERIVED FROM SOME LANTHANONS AND SOME TRANSITION METALS IONS WITH CARBOCYSTEINE AS PHARMACEUTICAL LIGAND

N. Abdel Ghany, Adel S. Orabi, N. B. El Assy, Sawssan M. Abuel Hassan

Abstract :

Proton–ligand dissociation constants of carbocysteine ligand and the formation constants of their complexes with some transition metal ions (Cu²⁺, Ni²⁺,Co²⁺, Zn²⁺, Fe³⁺) and some trivalent lanthanides (Ce⁺³, Pr⁺³, Er⁺³) ions have been determined potentiometrically in 0.1M KNO₃ in water. The effect of temperature was studied at 20, 30 and 40^oC, the thermodynamic parameters (DG₁, DH₁, DS₁) were evaluated and discussed. The stoichiometry of the formed complexes in solution was determined spectrophotometrically. The obtained data reveals the formation of 1:2 (metal : ligand) complexes. The solid complexes derived from the transition metal ions with ligand under investigation were prepared in ammonia solution as 1 : 2 metal : ligand stoichiometry.

The formed complexes were characterized by elemental analysis (C,H, N), IR, UV–Vis, X–ray and ¹H–NMR spectroscopy. The water content of the formed complexes was determined by thermal analysis (TG, DTA). The biological activities of the synthesized complexes were tested on different types of bacteria and fungi. Copper(II) complexes gave the maximum activities while Zn(II) and Ni(II) gave the minimum results.