Non–Retinal Histological Changes And Antihyperglycemic Activity of Cynodon Dactylon Extract In Streptozotocin Induced Diabetic Male Rats

MADHANKUMAR S J; CHRISTILDA FELICIA JEBAKANI

Volume : IV, Issue : XI, November - 2014

Non–Retinal Histological Changes And Antihyperglycemic Activity of Cynodon Dactylon Extract In Streptozotocin Induced Diabetic Male Rats

Madhankumar S J, Christilda Felicia Jebakani

Abstract :

The onset of diabetes mellitus at young age is increasing worldwide. Traditional Medicinal plants forms potential source of therapeutic agents. Cynodon dactylon possess anti–inflammatory, anti–ulcer and few researchers reported its Antihyperglycemic activity. The aim of this study is to determine the anti–hyperglycemic activity of Cynodon dactylon extract, and to observe any histological retinal changes in normal and streptozotocin induced diabetic male rats.The aqueous extract of Cynodon dactylon significantly (P<0.001) lowered the plasma glucose levels in STZ induced diabetic male rats, and also the histological observation of the retinal tissues of the normal, streptozotocin induced diabetic and diabetic treated groups, did not show any marked observable changes. These clearly indicate the efficacy and safety of Cynodon dactylon aqueous extract in streptozotocin induced diabetic male rats.  