Mitigating Effects of Triphala on Fluoride  Blood Toxicity in Rat

Rajendra N. Bhatt; Dhara D. Vyas; Raveendra B. Meda; Mandava V. Rao

Volume : III, Issue : XI, November - 2013

Mitigating Effects of Triphala on Fluoride Blood Toxicity in Rat

Rajendra N. Bhatt, Dhara D. Vyas, Raveendra B. Meda, Mandava V. Rao

Abstract :

Healthy adult female rats (Rattus norvegicus) were administered sodium fluoride (NaF) at the dose of 10 mg/ kg body weight and triphala at 30 mg/kg body weight orally. Both doses were given individually and also in combination for 30 days to investigate the fluoride toxicity in blood and its reversal by triphala. NaF feeding also ought about a significant decline in hemoglobin level, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) and red blood cell (RBC), which suggested occurrence of anemia and probable effect on haemopoetic system. Significant increase in erythrocyte sedimentation rate (ESR) indicates toxic effects in the body. Increase in white blood cells (WBC) count significantly suggests adverse effect of NaF treatment on the immune system of the rats. Co–administration of triphala to fluoride treated rats resulted in a partial effects in blood and body weight due to its probable protective role. Thus, triphala mitigated NaF induced toxicity marginally in a rat model.