Maternal Vitamin D Deficiency: A Risk Factor for Gestational Diabetes Mellitus in North India

Dr Rajni Dawar; Dr. Anita Devi; Dr. Manushri Sharma; Dr. Tabassum; Dr. Swati

Volume : VI, Issue : XI, November - 2016

Maternal Vitamin D Deficiency: A Risk Factor for Gestational Diabetes Mellitus in North India

Dr Rajni Dawar, Dr. Anita Devi, Dr. Manushri Sharma, Dr. Tabassum, Dr. Swati

Abstract :

Backgroud: Vitamin D is being increasingly recognized to have multiple non classical actions, such as promoting insulin action , secretion and immune modulation . Nuclear receptors for 1,25(OH)2D are discovered in a range of tissues including bone, intestine, kidney, lung, muscle and skin and pancreatic beta cells. The interaction of 1,25(OH)2D with nuclear vitamin D receptors influences gene transcription. This study aimed to estimate the levels of 25 OH Vitamin D in pregnant women with Gestational Diabetes Mellitus (GDM) and their glycemia control by HbA1c and its comparison with age and gestational age matched controls. Methodology: Hospital based case control study with 35 pregnant women diagnosed with GDM were taken as cases and 35 pregnant women age and gestational age matched without GDM were taken as controls. F. Plasma Glucose , HbA1c and Lipid profile were estimated using standard reagents and kits.25 OH Vit D levels were estimated by immunoassay system from Tosoh Biosciences. Results: Mean serum 25 OH Vit D levels in both the groups were coming <30 ng/ml which indicates vitamin D insufficiency. There was significant difference between 25OH Vit D levels in cases compared to controls with p<0.001. A significant inverse correlation was found between HbA1C and Vit D levels with (r = –0.499, p<0.001) in study group suggesting lower vit D levels in women with GDM have poor glycemic control. Conclusion: We found that vitamin D level in GDM patients were lower and correlated negatively with HbA1c as a glycemia control marker. Ours being a small study ,we would recommend population wide study of 25 OH Vit D in pregnancy to come to establish its role in GDM and its further inclusion in routine antenatal investigation.