Volume : V, Issue : III, March - 2015

Lupus Nephritis–A Life Threatening Renal Disease

Dr. Viveka Singh

Abstract :

Systemic lupus erythematosus (SLE) is an autoimmune disease in which organs and cells undergo damage mediated by tissue binding auto antibodies and immune complexes. Nephritis is the most serious manifestation of SLE leading to mortality in first decade of disease. We report a childpresenting with fever, joint pain,purpura, mouth ulcer,muco–cutaneous bleed and weight loss. He had pancytopenia withhypocomplementemia. Anti–nuclear antibodies and anti–double stranded DNA were positive. Serum lactate dehydrogenase, fiinogen, triglycerides, ferritin andcreatininewere elevated. Slit lamp examination revealed retinal hemorrhages with no uveitis. Two dimensional echo showed mild mitral valve and trivial mitral regurgitation. Bone marrow biopsy showed dilute marrow with mild hemophagocytosis.Renal biopsy showed diffuse proliferative lupus nephritis (grade IV). He was managed according to hemophagocyticlymphohistiocytosis (HLH) Protocol (2004) along with anti–hypertensives, Septran and Flucon prophylaxis. High index of suspicion, early diagnosis and treatment can be life saving.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Viveka Singh, Dr. Jyoti Sharma Lupus Nephritis â�‚�“ A Life Threatening Renal Disease Indian Journal of Applied Research, Vol.5, Issue : 3 March 2015

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