LIPID PROFILE AND SERUM URIC ACID LEVELS IN PATIENTS OF MYOCARDIAL INFARCTION: A CASE CONTROL STUDY

Dr. Jaidev Singh; Saman Amin; Dr. Rajesh Kumar

Volume : IX, Issue : VIII, August - 2019

LIPID PROFILE AND SERUM URIC ACID LEVELS IN PATIENTS OF MYOCARDIAL INFARCTION: A CASE CONTROL STUDY

Dr. Jaidev Singh, Saman Amin, Dr. Rajesh Kumar

Abstract :

Background: Hyperuricemia has been shown to increase the risk of CHD related–events such as MI independently of other CHD risk factors, and is linked to higher mortality rates of CHD. A recent meta–analysis have shown that each 1 mg/dL increase in serum uric acid, there is a 12% increase in mortality. Several studies have showed that deranged lipid metabolism is one of the major factors in the development of this ischemic heart disease. Material and Method: The study was carried out on 77 patients of myocardial infarction, and 72 controls. In the study we have investigated changes in lipid profile and serum uric acid in people suffering from myocardial infarction and compare these values with those of normal subjects. Healthy volunteers of 40–60 years who were not suffering from hypertension were selected randomly as controls from the hospital and college. Results: Study included 72 persons in control group while 77 patients of MI. Total Cholesterol, triglycerides, VLDL and uric acid was significantly elevated in hypertensive group (P<0.0001), while LDL and HDL levels were not significantly different between the two groups. Statistical analysis for males showed no difference between cases and controls for Cholesterol, TG, LDL, VLDL and uric acid (p>0.05). Among female population this difference of elevated parameters in MI group was significant for all the parameters. Conclusion: Significantly raised cholesterol, triglyceride, VLDL and Serum uric acid levels are associated with myocardial infarction while HDL and LDL levels show no statistical association.