Iron profile parameters status in sickle cell disease patients: a case control study from Chhattisgarh India

Dr. Vandana Dewangan; Dr. Sharja Phuljhele; Dr. Dnyanesh Amle; Dr. P. K. Patra

Volume : X, Issue : V, May - 2020

Iron profile parameters status in sickle cell disease patients: a case control study from Chhattisgarh India

Dr. Vandana Dewangan, Dr. Sharja Phuljhele, Dr. Dnyanesh Amle, Dr. P. K. Patra

Abstract :

Sickle cell disease subjects are at risk of imbalance in iron and related parameters due to hemolytic pathophysiology and bone marrow stress. Frequent blood transfusion further causes the imbalance to escalate. We tried to assess various hematological parameters in Sickle cell disease subjects in state of Chhattisgarh and compare the parameters in Sickle cell trait and normal subjects. Materials and methods: 200 subjects each with sickle cell disease (SCD), Sickle cell trait (SCT) and Normal healthy control subjects (C) as per High performance liquid chromatography and electrophoresis reports. All the subjects were assessed with hematological and iron profile parameters. These parameters were compared between groups. Results: All the hematological parameters were found to be significantly different between study groups. On post hoc analysis, Hb and RBC were found to be significantly lower in study groups SS as compared to AA and AS, while WBC was found to be significantly higher in study groups SS as compared to AA and AS. Frequency of low S. iron levels, high S. ferritin levels high TIBC levels and low transferrin saturation levels was significantly higher in SS group. Conclusion: Serum transferrin is significantly reduced while serum ferritin is significantly increased in sickle cell disease subjects. This indicates high saturation of iron in sickle cell disease subjects. In the backdrop of frequent blood transfusion required in SCD subjects, this finding must be kept in mind while administrating blood transfusion.