Ionization of Perindopril Permadiol and Amineptine–HCl as Pharmaceutical Ligands and Their Complexes  with Divalent cations and Lanthanons

N. Abdel-Ghany; Adel S. Orabi; N.B. El-Assy; Sawssan M. Abu El-Hassan

Volume : III, Issue : XII, December - 2013

Ionization of Perindopril Permadiol and Amineptine–HCl as Pharmaceutical Ligands and Their Complexes with Divalent cations and Lanthanons

N. Abdel Ghany, Adel S. Orabi, N. B. El Assy, Sawssan M. Abu El Hassan

Abstract :

Proton–constants of Per(I) and Amin(II) ligands and the formation constants of their complexes with some transition metal ions Zn(II) and Cu(II) and some trivalent lanthanides Ce(III), Pr(III) and Er(III) ions have been determined potentiometrically in aqueous methanol medium. The effect of temperature was studied at 2o, 3o and 40oC. The thermodynamic parameters (?Ho, ?Go, ?So) were evaluated and discussed. The formation constants for the investigated metal complexes were calculated.