IMPRINT AND SCRAPE SMEAR CYTOLOGY AS A RAPID DIAGNOSTIC TOOL

Jayasree Geothe

Volume : VI, Issue : III, March - 2016

IMPRINT AND SCRAPE SMEAR CYTOLOGY AS A RAPID DIAGNOSTIC TOOL

Jayasree Geothe

Abstract :

 Background: Intra operative pathological assessment has offered a very valuable service in patient management. Frozen section (FS) is routinely used by many surgical pathology laboratories and has been the mainstay of rapid diagnosis in histopathology laboratories. Nonetheless, certain relative limitations and precautions still exists can result in grave mistakes that will be detrimental to the patient’s management. In many centers frozen section facility not available .Many studies have been done in the past to evaluate the role of cytology in intra operative diagnosis. Aim and objectives: To evaluate the utility of imprint /scrape cytology for the rapid diagnosis of surgically removed specimens and its utilization for learning cytopathology. Materials and Methods: 130surgically removed specimens from various organs and systems were studied. Smears were taken from each specimen before formalin fixation and stained by modified rapid H&E and Papanicolaou staining. Cytological diagnosis was made and then results were compared with the histological diagnosis taking the latter as the gold standard. Results: Out of the 130 cases sampled, 130 were satisfactory for evaluation. Overall accuracy rate was 96.15% and in.107 cases could be specifically diagnosed as nonneoplastic/ benign and malignant tumors(82.3%).Two cases of false positive diagnosis(5.9%) and 3 false negative diagnosis(3.1%) were made .Positive predictive value was 97.9% and negative predictive value was 91.4%.. Conclusions: Imprint /scrape cytology is a good complement for the rapid diagnosis in histopathological study of tumor/tumor like lesions and intra operative cytology can be used an adjunct to frozen section. In addition the skill and expertise developed by routinely practicing intra operative cytological technique can be applied to the interpretation of FNAC.