Hepatoprotective effect of olive and coconut oils against oxidative stress– induced by 2, 4 Dichlorophenoxyacetic acid

Hanaa M. Abd El-Fattah; Lamiaa A.A. Barakat

Volume : III, Issue : XII, December - 2013

Hepatoprotective effect of olive and coconut oils against oxidative stress– induced by 2, 4 Dichlorophenoxyacetic acid

Hanaa M. Abd El Fattah, Lamiaa A. A. Barakat

Abstract :

The effect of dietary olive and coconut oils on liver damage and oxidative stress induced by 2, 4–Dichlorophenoxyacetic acid(2,4–D) in rats was evaluated. 48 male adult albino rats were divided into 6 groups (8 for each group). Group1: rats fed on basal control diet, group2: rats fed on control diet and administrated orally 24 mg 2, 4–D/ kg body weight/twice a week, groups 3 and 5: rats fed on virgin olive diet or coconut diet respectively, groups 4 and 6: rats fed on olive diet or coconut diet respectively and administrated 25 mg 2, 4–D/ kg b.wt/ twice a week for six weeks. Results: A significant liver damage was observed in rats treated with 2, 4–D via an increase in serum transaminases and alkaline phosphatase enzymes activities, hepatic lipid peroxidation and liver free fatty acids, while serum total protein and albumin, hepatic superoxide dismutase and glutathione peroxidase enzymes activities were significantly reduced with the presence of some inflammations and necrosis in liver sections of 2, 4– D treated rats. However, virgin olive and coconut oils administration during 2, 4–D treatment induced an improvement in hepatic antioxidant enzymes, serum transaminases activities and liver free fatty acids levels. Biochemical results were confirmed by the liver histopathological examination. Conclusion: olive oil and coconut oil have protective effect against oxidative stress and liver damage induced by 2, 4–D.