Evaluation of In vitro Antidiabetic activity of silver nanoparticles synthesized from Azima tetracantha leaf

Manimegalai B; Velavan S

Volume : VII, Issue : VII, July - 2017

Evaluation of In vitro Antidiabetic activity of silver nanoparticles synthesized from Azima tetracantha leaf

Manimegalai B, Velavan S

Abstract :

The aim of the current work is to screen in vitro inhibition of alpha–amylase and α–glucosidase enzyme activities in silver nanoparticles synthesized from Azima tetracantha leaf extract. This in vitro study explores the antidiabetic properties of biosynthesized silver nanoparticles and it can be considered as a potential candidate for the management of type–II diabetes mellitus. The present findings exhibited a concentration dependent inhibition of α–amylase and α–glucosidase activity by the Azima tetracantha leaf extract and AgNPs. The half inhibition concentration (IC₅₀) of Azima tetracantha leaf extract, AgNPs and Acarbose tested against α–amylase were 288.79, 262.18μg/ml–1 and 246.14μg/ml–1 respectively. The half inhibition concentration (IC₅₀) of Azima tetracantha leaf extract, AgNPs and Acarbose tested against α–glucosidase were 315.23, 271.78μg/ml^–1and 266.72μg/ml^–1respectively. The results of the study revealed that the antidiabetic activity of the AgNPs is much higher than the Azima tetracantha leaf extract and near to the standard antihyperglycemic drug.