EVALUATION OF CLINICAL UTILITY OF TSH AS A BIOMARKER IN THE SUSPECTED CASES OF THYROID MALIGNANCY

Dr. Arun Kumar; Dr. Shyam Sunder Nagpal

Volume : X, Issue : V, May - 2020

EVALUATION OF CLINICAL UTILITY OF TSH AS A BIOMARKER IN THE SUSPECTED CASES OF THYROID MALIGNANCY

Dr. Arun Kumar, Dr. Shyam Sunder Nagpal

Abstract :

Introduction: Thyroid malignancies account for 90% of endocrinal malignancies. The incidence of thyroid malignancies has increased three–fold over the past 3 decades. Many patients present to the surgical outpatient department with a thyroid nodule. A clinical examination is always the first step to assess a nodule. A thyroid profile is also essential. Recent studies have found levels of serum TSH to be an independent predictor of malignancy in thyroid nodules This biomarker could be used as a screening test for malignancy. Objectives of the study: To evaluate the utility of serum TSH estimation as a biochemical predictor of malignancy in suspicious thyroid nodules Materials and Methods: All patients were admitted and a detailed history and clinical examination was done and investigated as per the written proforma. Informed consent was taken and thyroid profile and a FNAC was done in all cases. Results: A total of 44 subjects with the inclusion criteria and exclusion criteria protocol were enrolled in the study. Out of the 40 subjects, 6 were males, 38 were females. Most of the subjects belong to the age group of 41–50 years. We found elevated TSH (>5 mIU/L) in 5 subjects, 26 subjects had TSH levels between 1.60–4.99 and 13 subjects had TSH values between 0.34–1.59. Incidence of malignancy among the subjects with TSH levels >5mIU/L were 4. Conclusion: TSH levels could be used as predictor in clinically suspect malignant thyroid swelling with a benign FNAC report. In such cases where TSH value is high, the FNAC can be relooked to confirm the diagnosis.