Volume : III, Issue : VII, July - 2013
Evaluation of Antioxidant and Antitumor Activities of Some Prepared Nitrogen Heterocycles
Mohamed Abd El Moneim, Ibrahim M. El Deen, Wessam Abd El Fattah
Abstract :
4–Benzylidene–2–(p–chlorophenyl)–4H–oxazol–5–one (2) was prepared via cylcocondensation of N–(p–chlorobenzoyl) glycine with benzaldehyde in presence of fused sodium acetate and acetic anhydride. Condensation of 2 with semicarbazide hydrochloride in presence of fused sodium acetate afforded the corresponding 3,5–disubituted–2–(aminocarbonyl)–1,2,4–triazine–6–one (3). Acetylation of 3 with acetic anhydride yielded the monoacetyl and diacetyl derivatives (4 and 5). Methyl α–(p–chlorobenzoyl) amino–β–phenyl acrylate (6) was synthesized via the reaction of 2 with triethylamine in methanol. 5,6–disubstituted–4–hydroxypyrimidine–2–thiole (7) was obtained via cyclocondensation of ester (6) with thiourea in presence of anhydrous potassium carbonate. Synthesized compounds were characterized by EI–MS and NMR spectroscopy. The biological activity studies of triazines and pyrimidine–2–thiole were carried out against antioxidant and antitumor activities.
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DOI : 10.36106/ijar
Cite This Article:
Mohamed Abd El-Moneim, Ibrahim M. El-Deen, Wessam Abd El-Fattah Evaluation of Antioxidant and Antitumor Activities of Some Prepared Nitrogen Heterocycles Indian Journal of Applied Research, Vol.III, Issue.VII July 2013
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Mohamed Abd El-Moneim, Ibrahim M. El-Deen, Wessam Abd El-Fattah Evaluation of Antioxidant and Antitumor Activities of Some Prepared Nitrogen Heterocycles Indian Journal of Applied Research, Vol.III, Issue.VII July 2013
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