Evaluation and comparison of Fentanyl and  Sufentanil as adjuvants to intrathecal Bupivacaine

Dr. Tejasi Waigankar; Dr. Kalyani N. Patil

Volume : I, Issue : II, October - 2012

Evaluation and comparison of Fentanyl and Sufentanil as adjuvants to intrathecal Bupivacaine

Dr. Tejasi Waigankar, Dr. Kalyani N. Patil

Abstract :

Objectives: To evaluate Fentanyl and Sufentanil as adjuvants to intrathecal hyperbaric Bupivacaine with respect to: 1. Sensory and motor block characteristics., 2. Analgesia., 3. Haemodynamic variables., 4. Adverse effects. Methods: In a prospective, randomized, comparative, double–blind study, 90 patients requiring subarachnoid block were recruited into three groups. Group A received 3ml 0.5%bupivacaine+0.5ml normal saline. Groups B and C received 25μg Fentanyl and 5μg Sufentanil respectively as adjuvants to bupivacaine. Observations and Results: Onset, time to maximum motor block and duration of motor block were comparable. Onset, highest sensory level and time required to achieve it were comparable. Opioids significantly prolonged duration of regression to T10, duration of sensory block and analgesia and caused significant pruritis. Conclusion: Opioids prolong duration of sensory block and analgesia without enhancing motor block. Sufentanil provides longer analgesia than Fentanyl. Haemodynamic changes are insignificant. Adverse effects are mild.