DIURNAL VARIATION OF SERUM UREA , URIC ACID AND CREATININE IN HEALTHY INDIVIDUALS

Aabha Malviya; Dr.A.D.Deepak; Apurva Jha; Amrita Malviya

Volume : VI, Issue : III, March - 2016

DIURNAL VARIATION OF SERUM UREA , URIC ACID AND CREATININE IN HEALTHY INDIVIDUALS

Aabha Malviya, Dr. A. D. Deepak, Apurva Jha, Amrita Malviya

Abstract :

 Objectives: The aim is to study diurnal variations of serum NPNs urea ,uric acid and creatinine in healthy individuals. Study Design: observational & prospective Place and Duration of Study: The study was carried out in Department of Biochemistry and department of Medicine, MGM Medical college, Navi Mumbai. Methodology: Total 70 subjects comprising of male and female aged between 18 to 35 years were recruited in the study after obtaining informed written consent. The serum levels of urea, uric acid and creatinine were estimated three times a day at morning 8am, afternoon 1pm, and evening 6pm. The mean serum urea level, uric acid level and serum creatinine at various durations was compared using one way ANOVA. Results: In our study, we found strong correlation of serum creatinine level after overnight rest morning fasting sample with sample collected in the afternoon and evening. Whereas, we have not observed any significant variation in the case of serum urea and uric acid levels.