DIAGNOSTIC UTILITY OF IMMUNOHISTOCHEMICAL MARKERS CK7,CK 20 AND CEA IN SURFACE EPITHELIAL TUMORS OF OVARY

Dr. Mahendra Singh; Dr. Nidhi Verma

Volume : X, Issue : II, February - 2020

DIAGNOSTIC UTILITY OF IMMUNOHISTOCHEMICAL MARKERS CK7,CK 20 AND CEA IN SURFACE EPITHELIAL TUMORS OF OVARY

Dr. Mahendra Singh, Dr. Nidhi Verma

Abstract :

BACKGROUND: Immunohistochemistry is confirmatory test in that cases where definitive diagnosis is not made on morphological & histological basis.IHC helpful in classification of tumors.It also helpful in resolving diagnostic dilemma in closely mimicking and poorly differentiated tumours. MATERIAL AND METHODS:We received 100 biopsy of different cases of surface epithelial tumors of ovary in period of 2 years.3 immunomarker were included in the study.RESULT:Out of 100 case 70% are benign and 30% are malignant.Serous cystadenoma was most common benign lesion(60%)& among malignant lesions Serous cystadenocarcinoma was most common(60%).83.33% cases of serous carcinoma showed positivity for CK7 & 100% negativity for CK20 & CEA.CONCLUSION: IHC is helpful in classification & confirmation of the histological diagnosis. IHC is particularly helpful in resolving diagnostic dilemma in closing mimicking and poorly differentiated ovarian tumors.