Diagnositic Utility of Serum Adenosine Deaminase  and Liver Function Tests in Tuberculosis and Hiv  Patients

Dr. Amit P. Trivedi; Dr. Kiran P. Chauhan; Dr. N Haridas

Volume : III, Issue : X, October - 2013

Diagnositic Utility of Serum Adenosine Deaminase and Liver Function Tests in Tuberculosis and Hiv Patients

Dr. Amit P. Trivedi, Dr. Kiran P. Chauhan, Dr. N Haridas

Abstract :

Adenosine deaminase is a catabolic enzyme, of the purine catabolic pathway. The function of ADA also is related to the development of immune system and cell differentiation in human. The global incidence of tuberculosis (TB) has sharply increased particularly in areas where HIV and tuberculosis are both prevalent. The Adenosine deaminase activity was found to be elevated in the fluid sample of most of the suspected cases of Tuberculosis and HIV. But it has been observed that in the patients presented with typical clinical picture of tuberculosis infection and HIV, the adenosine deaminase activity in serum is much above the reference range. The Adenosine deaminase activity along with the lymphocyte to Neutrophils ratio, total leucocytes count and protein electrophoresis can be used as a diagnostic test for the diagnosis of HIV and HIV plus tuberculosis infection. The study consists of 37 patients with HIV infection, 33 patients with HIV and tuberculosis and 43 patients who suffered from tuberculosis and 25 normal subjects. All the serum samples were analyzed for ADA, Serum Total Proteins, Albumin, Globulin, Serum Alkaline Phosphatase, Serum Alanine Transaminase, Serum Aspartate Transaminase and Serum Total Bilirubin. HIV patients had significantly higher ADA levels compared to normal controls. TB Patients also had significantly higher ADA and Total Leucocyte count when compared to normal controls. Comparison of normal subjects with patients suffering with both HIV and TB showed that the patients had signifcantly higher ADA and Alkaline phosphatase levels