Volume : IX, Issue : VI, June - 2019
Development of a new green protocol for the Biginelli reaction employing readily available catalysts
S. R. Jagtap, B. B. Bahule, R. P. Yadav, Khursheed Ahmad
Abstract :
A new methodology is designed for the preparation of 1,2,3,4 tetra–hydro pyrimidine derivatives starting from the aromatic aldehyde in combination with ethyl acetoacetate , urea and catalyst like ammonium acetate, cetyl trimethyl ammonium omide and tetra–decyl trimethyl ammonium omide. A three component condensation was carried out in ethanol . The reaction was completed in 1 hour at 80 o C . The products were isolated , purified by column chromatography and characterised by IR and PMR data. The catalysts used arecheaper , easily available and can be recovered, recycled .The pyrimidine derivatives thus obtained are expected to possess some biological activity by the virtue of pyrimidine moiety.
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DOI : 10.36106/ijar
Cite This Article:
DEVELOPMENT OF A NEW GREEN PROTOCOL FOR THE BIGINELLI REACTION EMPLOYING READILY AVAILABLE CATALYSTS, S. R. Jagtap, B.B. Bahule, R. P. Yadav, Khursheed Ahmad INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-6 | June-2019
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DEVELOPMENT OF A NEW GREEN PROTOCOL FOR THE BIGINELLI REACTION EMPLOYING READILY AVAILABLE CATALYSTS, S. R. Jagtap, B.B. Bahule, R. P. Yadav, Khursheed Ahmad INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-6 | June-2019
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