Volume : VIII, Issue : VI, June - 2018

Cytogenetics and Genetic Counseling in Bad Obstetric History.

Radhika Kedar, R J Verma, Divya Chandel

Abstract :

About 15% to 20% of pregnancies end in spontaneous abortion (SA), mostly in the first trimester of whichatleast 50% result from chromosomal abnormalities.TheTORCH (toxoplasmosis, rubella virus, cytomegalovirus and herpes simplex virus) infections are the most common infectious agents causing serious pregnancy outcome.The study aimed to perform karyotyping and genetic counselingin couples with bad obstetric history(BOH). A detailed proforma was filled for each casefollowed by peripheral blood lymphocyte cultures and G banding.In the Case 1, the wife had a reciprocal translocation with karyotype 46,XX,t(2;10)(q31;q25) and was also positive for TORCH test done previously. In the Case 2, the husband had a reciprocal translocation with karyotype 46,XY,t(q13;q32).Although in Case 1, the female was positive for TORCH test, this infection may be cause for single miscarriage but not a cause for repeated miscarriage. Therefore, karyotyping should be a mandatory etiological investigation followed by genetic counseling in all couples with BOH.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Radhika Kedar, R J Verma, Divya Chandel, Cytogenetics and Genetic Counseling in Bad Obstetric History., INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-6 | June-2018

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