Correlation of HER 2 and E-cadherin expression with clinicopathological features in gastric cancer

Dr Nisha M Das; Dr Sunitha Balakrishnan; Dr Suchitra ET

Volume : IX, Issue : III, March - 2019

Correlation of HER 2 and E-cadherin expression with clinicopathological features in gastric cancer

Dr Nisha M Das, Dr Sunitha Balakrishnan, Dr Suchitra Et

Abstract :

HER2 and E–cadherin are two predictive biomarkers in gastric cancer. This study was proposed to establish the expression of HER2 and E–cadherin in gastric adenocarcinoma and to find its correlation with different histopathological features. A total of 65 patients with gastric adenocarcinoma were included in the study. Histopathological examination and IHC studies were done on gastrectomy specimens received in Department of Patholgy, Medical College, Thrissur Kerala. The intestinal variant of gastric cancer was the most common among the samples (37; 56.92%) and most of the patients had moderately differentiated (26, 40%) adenocarcinoma. Overall, 4 (6.15%) patients had tumors that were scored as HER 3+, and 9 (13.85%) patients had tumors that were scored as E–cadherin +3. None of the clinicopathological features had a significant association with HER 2 or E–cadherin expression. Larger studies with standardized testing and scoring are required before using these biomarkers in targeted therapy