Comparison of Ropivacaine and Ropivacaine with Clonidine for Caudal Analgesia in Pediatric Patients for Lower Abdominal Surgeries

NILESH S. JAWE; MARUTI PAWAR; ULHAS MISAL

Volume : VI, Issue : IX, September - 2016

Comparison of Ropivacaine and Ropivacaine with Clonidine for Caudal Analgesia in Pediatric Patients for Lower Abdominal Surgeries

Nilesh S. Jawe, Maruti Pawar, Ulhas Misal

Abstract :

AIM The aim of the present study was to compare the post–operative pain relieving quality of ropivacaine 0.25% and clonidine mixture to that of plain ropivacaine 0.25% following caudal administration in children. METHOD In a prospective, double–blinded, randomized controlled trial, 80 ASA I, II pediatric patients undergoing infraumbilical surgery were randomly allocated to receive a caudal injection of either plain ropivacaine 0.25% (0.5 ml/ kg) (group A) or a mixture of ropivacaine 0.25% (0.5 ml/kg) with clonidine 1 μg/kg (group B). Objective pain score and need for supplemental analgesics were compared during the 1st 24 hours postoperatively. Residual post–operative sedation and motor blockade were also assessed. RESUITS Significantly prolonged duration of post–operative analgesia was observed in group B (P<0.0001). Heart rate and blood pressure were not different in 2 groups. Neither motor blockade nor post–operative sedation varied significantly between the groups. Conclusion: Addition of clonidine 1 mcg/kg to 0.25% ropivacaine for caudal analgesia significantly prolongs the duration of analgesia in the post–operative period with minimal changes in the hemodynamic parameters without any side effects. Therefore, we conclude that 0.25% ropivacaine with 1 mcg/kg clonidine has better post–operative analgesia when compared to plain ropivacaine.