COMPARISON OF POST-OPERATIVE ANALGESIA AFTER INTRATHECAL NALBUPHINE WITH BUPIVACAINE AND INTRATHECAL FENTANYL WITH BUPIVACAINE FOR SUBARACHNOID BLOCK IN PATIENTS UNDERGOING LOWER ABDOMINAL AND LOWER LIMB SURGERIES: A RANDOMIZED DOUBLE BLINDED CLINICAL TRIAL.

Dr. Narendra Malineni; Dr. Narayana Swamy D. K

Volume : IX, Issue : II, February - 2019

COMPARISON OF POST-OPERATIVE ANALGESIA AFTER INTRATHECAL NALBUPHINE WITH BUPIVACAINE AND INTRATHECAL FENTANYL WITH BUPIVACAINE FOR SUBARACHNOID BLOCK IN PATIENTS UNDERGOING LOWER ABDOMINAL AND LOWER LIMB SURGERIES: A RANDOMIZED DOUBLE BLINDED CLINICAL TRIAL.

Dr. Narendra Malineni, Dr. Narayana Swamy D. K

Abstract :

The study was made to compare clinical efficacy of nalbuphine and fentanyl as adjuvant to hyperbaric bupivacaine in patients undergoing infraumblical surgeries under subarachnoid block. Patients and methods: A total of 100 patients of ASA status I and II aged 20 to 60 years undergoing lower abdominal and lower limb surgeries under spinal anaesthesia were randomized into two groups as Group N: receiving inj. Bupivacaine hyperbaric 0.5% 3 ml + inj. Nalbupine 500mcg and Group F: receiving inj. Bupivacaine hyperbaric 0.5% 3 ml + inj. Fentanyl 25mcg intrathecally. Results: The onset of sensory and motor blocks and the duration of sensory and motor blocks were comparable in both the groups. The duration of postoperative analgesia (in min) was 322.10±20.39 in Group N and 248.28±17.73 in Group F (p<0.005) with statistically significant difference between groups. Conclusion: Intrathecal nalbuphine when added to hyperbaric bupivacaine as an adjuvant provides clinically more efficient and better quality of block as compared to fentanyl. It also prolongs postoperative analgesia for 6–7 hrs (322 ±20min) when compared to fentanyl (248±17 min) when used as an adjuvant without any significant adverse effects for patients undergoing lower abdominal and lower limb surgeries under subarachnoid block.