Volume : VII, Issue : VI, June - 2017
COMPARATIVE STUDY OF EFFICACY AND SAFETY OF GABAPENTIN AND AMITRIPTYLINE MONOTHERAPY IN PATIENTS OF PAINFUL DIABETIC NEUROPATHY
Dr. Jayesh Rajgopal, Dr. A. K Srivastav
Abstract :
The objective of this study was to compare the efficacy and safety of gabapentin and amitriptyline monotherapy in painful diabetic neuropathy. This was a 12 weeks, observational, open label, comparative, multiple followup study. A total of 110 patients were included in the study with 55 patients in patients receiving gabapentin and 55 patients receiving amitriptyline. Treatment was provided for a period of 12 weeks and patients was called for follow up at 4, 8 and at 12 weeks (3 follow ups). Baseline assessment was done by Biochemical tests consisting of CBC, serum creatinine, serum Urea, liver function tests, HbA1c. At the time of follow up patient were be evaluated for efficacy, safety and tolerability. Results were comparable with no significant statistical difference. Monotherapy with gabapentin and amitriptyline produced a clinically and subjectively meaningful pain relief in patients with diabetic painful neuropathy with onset of pain relief being fast.
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DOI : 10.36106/ijar
Cite This Article:
Dr. Jayesh Rajgopal, Dr. A.K Srivastav, COMPARATIVE STUDY OF EFFICACY AND SAFETY OF GABAPENTIN AND AMITRIPTYLINE MONOTHERAPY IN PATIENTS OF PAINFUL DIABETIC NEUROPATHY, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾6 | June‾2017
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Dr. Jayesh Rajgopal, Dr. A.K Srivastav, COMPARATIVE STUDY OF EFFICACY AND SAFETY OF GABAPENTIN AND AMITRIPTYLINE MONOTHERAPY IN PATIENTS OF PAINFUL DIABETIC NEUROPATHY, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾6 | June‾2017
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