Comparative Study of Anti – Emetic Efficacy  of Palonosetron with Ondansetron And  Metoclopramide

Dr Sumesh T. Rao; Dr Madhusudan Upadya; Dr Karthik Narendrakumar; Dr Deepa T

Volume : III, Issue : X, October - 2013

Comparative Study of Anti – Emetic Efficacy of Palonosetron with Ondansetron And Metoclopramide

Dr Sumesh T. Rao, Dr Madhusudan Upadya, Dr Karthik Narendrakumar, Dr Deepa T

Abstract :

Aim: This study was designed to assess the safety and efficacy of palonosetron in comparison with ondansetron and metoclopramide administered intravenously before general anesthesia for prevention of post operative nausea and vomiting. Patients and methods: A randomized prospective study was carried out in 60 patients aged 18–65 yrs of ASA grade I, II and III. They were categorized into 3 groups. Group P (n = 20) received Inj: palonosetron 0.25mg, Group O (n = 20) Inj: ondansetron 4 mg and Group M (n = 29) Inj: metoclopramide 10 mg. Results: Statistically, no significant difference was found in the anti–nausea efficacy of palonosetron compared to ondansetron and metoclopramide. Compå overall incidence of vomiting showed that the antiemetic efficacy of palonosetron is the same as ondansetron and metoclopramide for post–operative emesis.