COMPARATIVE ASSESSMENT OF SUBCLINICAL CAROTID ATHEROSCLEROSIS IN HIV PATIENTS AND HEALTHY CONTROLS BY ULTRASONOGRAPHY & ITS CORRELATION WITH ANTIRETROVIRAL THERAPY

Sheikh Abdul Raheem; Aneesh Mohimen; Sunita Patil; Samaresh Sahu; Akhilesh Rao; Bhanu Pratap Singh

Volume : IX, Issue : VIII, August - 2019

COMPARATIVE ASSESSMENT OF SUBCLINICAL CAROTID ATHEROSCLEROSIS IN HIV PATIENTS AND HEALTHY CONTROLS BY ULTRASONOGRAPHY & ITS CORRELATION WITH ANTIRETROVIRAL THERAPY

Sheikh Abdul Raheem, Aneesh Mohimen, Sunita Patil, Samaresh Sahu, Akhilesh Rao, Bhanu Pratap Singh

Abstract :

Background: The study was planned to detect an association of HIV infection and sub–clinical atherosclerosis in the form of increased carotid intima–media thickness (IMT) Methods: 50 HIV patients and 50 matched healthy controls were studied. The HIV patients were further sub classified into those on ART or not on ART. All of them underwent carotid doppler to identify subclinical atherosclerosis in the form of presence of either pathological intima–media thickness (IMT) or atherosclerotic plaque. Mean IMT was calculated in various groups and the statistical analysis done. Results: The mean IMT in the test group (HIV), ART, Non ART, control groups was 0.746 mm (SD 0.181), 0.817 mm (SD 0.167), 0.58 mm (SD 0.068) ,0.572 mm (SD 0.101) respectively. There is significant difference in the mean IMT of HIV Vs control groups, ART Vs Non ART sub groups. There is no significant difference in mean IMT of Non ART Vs Control group. Conclusion: HIV patients have higher prevalence of subclinical atherosclerosis and significantly higher mean IMT as compared to Healthy controls. The prevalence of subclinical atherosclerosis is even higher in ART treated HIV patients.