Clinical & Histopathological analysis of presumed Ocular Surface Squamous neoplasia(OSSN).

Madan Joshi; Subrahmanya Bhat.K; Vijay Pai

Volume : IX, Issue : III, March - 2019

Clinical & Histopathological analysis of presumed Ocular Surface Squamous neoplasia(OSSN).

Madan Joshi, Subrahmanya Bhat. K, Vijay Pai

Abstract :

BACKGROUND – Ocular surface squamous neoplasia (OSSN) is an encompassing term for precancerous and cancerous epithelial lesions of the conjunctiva and cornea. It includes the spectrum of dysplasia, Carcinoma In Situ (CIN), and invasive Squamous Cell Carcinoma (SCC). In recent times, the incidence of OSSN seems to be on the rise, especially in developing countries like India. AIM–To analyze the clinical presentation and Histopathological features of presumed OSSN. DESIGN – Retrospective cross–sectional study. METHODS – We analyzed 27 patients with suspected OSSN from June 2017 – May 2018. Patients were examined to determine the type, location, corneal involvement. All patients underwent excision biopsy with 4mm free margin. RESULTS – 19(70.3%)cases out of 27 were histopathological proven OSSN. Age range of patients was found to be 13 to 79 years, mean age being 55.20 years. Majority of patients were males accounting for 68%. Gelatinous type is the most common clinical variety. 2 patients had Xerdoderma pigmentosa(XP) and 5 were tested positive for HIV. CONCLUSION – OSSN is more commonly found in males and outdoor workers and also has positive association with XP and HIV. Leukoplakic type is commonest variety. Thorough knowledge of clinical presentation and clinical examination is necessary for an ophthalmologist and surgical excision with a clear margin should be done in all doubtful cases of OSSN.