Volume : VIII, Issue : III, March - 2018
Circulating tumor markers of benign and malignant breast disorders in Libya
A. M. Jarari, Satyanarayana Chanamallu, Saeid Omer Alsaeoti, Hayam El Awamy, Noah Mohammed Jarari, Munira G Gadeer, Shakila Srikumar, Sainath Jagannadh Dhoipode, Dawoodi Fakruddin, Avinash K Rawal, Jagannadha Rao Peela, Aaren Vedangi
Abstract :
Background:Breast cancer is most common malignant disorder in Libyan females. Breast cancer is the most dreadful disease in terms of quality of life, though heart disease is a more common cause of mortality here. Benign and malignant east disorders are very common in Libyan women like other Arab countries particularly younger individuals than western world. An increase in the incidence of cancers has been reported in the Arab countries [1]. This could be explained by the attribution of various factors such as the robust epidemiological control of infectious diseases, increase in the average life span of the general population, higher socio–economic status, smoking, higher incidence of hepatitis B and C, and food fads socio–economic status. Breast cancer is one of the leading cancers, causing higher rate of morbidity and mortality comparable to that of other developed countries, however, with an earlier age of onset [2]. 26% of all cancers are east cancers in Libyan women as per the Benghazi cancer registry. [3]. Almost a decade ago, Singh and Al–Sudani [4] demonstrated that east cancer is one of the top ten cancers responsible for higher mortality in Libya. In another study conducted between 1981 and 1985 [5], east cancer was the most frequent tumor (29.8%) in females and the majority of these patients were of a younger age group (72.3% below 50 years). Almost all the patients selected for our study were multiparous and were exposed to east–feeding [6]. A recent literature review by Najjar and Easson [6] provided evidence that the average age of onset of east cancer in Arab women is 48 years and is almost a decade sooner than their western counterparts and this warrants effective screening and management strategies [7]. The present study is a case control study of tumour markers CA 125, CA 15–3 and Carcino Emyonic Antigen (CEA) in serum of patients suffering from benign and malignant east disorders in Libya.
Materials and methods: There are 12 cases of carcinoma of east patients with age group ranging from 30 – 55 years of age, 10 cases of benign east disorders i.e., Fioadenosis with age group ranging from 18 to 50 years retrieved from department of surgery, 7th October Hospital, Benghazi, Libya and there are 12 cases of age matched controls free from both malignant and benign disorders of east were included in this study. Venous sampling was done to the patients, all the patients and controls were measured serum CA125, CA15–3and CEA levels by authenticated methods by using Cobas E 411 analyser. Statistical analysis was done by using SPSS software by using Mann–Whitney and Wilcoxon tests.
Results: There is no significant rise of CA 125 in benign (p=0814) and malignant (p= 0.676) disorders of east when compared to controls. CA 15–3 was significantly high in patients suffering from east cancer (p= 0.019) when compared to controls and also very significantly high when (p= 0.003) compared with patients with benign east disorders. The level of CA 15–3 was not significantly high in patients with benign east disorders (p=0.186) when compared to controls. The level of CEA was significantly high in patients of east cancer when compared to patients of benign east (p=0.009) disorders and (p=0.017) controls. The level of CEA is not significantly in high patients of benign east disorders (p=0.634) when compared to controls.
Conclusion: The present study showing high levels CA 15–3 and CEA only in malignant disorders of east may be useful as diagnostic and prognostic markers. CA 125 has not shown any significance in this study proving that it is not an important marker in malignant east disorders.
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DOI : 10.36106/ijar
Cite This Article:
A. M. Jarari, Satyanarayana Chanamallu, Saeid Omer Alsaeoti, Hayam El Awamy, Noah Mohammed Jarari, Munira G gadeer, Shakila Srikumar, Sainath Jagannadh Dhoipode, Dawoodi Fakruddin, Avinash K Rawal, Jagannadha Rao Peela, Aaren Vedangi, Circulating tumor markers of benign and malignant breast disorders in Libya, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-3 | March-2018
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A. M. Jarari, Satyanarayana Chanamallu, Saeid Omer Alsaeoti, Hayam El Awamy, Noah Mohammed Jarari, Munira G gadeer, Shakila Srikumar, Sainath Jagannadh Dhoipode, Dawoodi Fakruddin, Avinash K Rawal, Jagannadha Rao Peela, Aaren Vedangi, Circulating tumor markers of benign and malignant breast disorders in Libya, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-3 | March-2018
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