Volume : IV, Issue : I, January - 2014
Characterization of IVS–110,IVS–6 and Codon 39 beta–thalassemia mutations using amplification refractory mutation system (ARMS) technique in Bisha, Saudia Arabia
Dr. Khaled Ismail Ghaleb, Dr. Mohamed Metwaly Mohamed
Abstract :
The current study aim to characterized the thalassemia mutations in Bisha,Saudia rabia using amplification refractory mutation system(ARMS) in detection of the IVSI-110, IVSI-6 and codon 39 mutations. The study comprised of 50 cases from King Abdullah hospital, 20 females and 30 males and the age between 3 -25 years. The result revealed that IVS110 were7 cases (14%) homozygous and 15 cases (30%) heterozygous, IVSI-6 were 6 cases(12%) homozygous and 16 cases(32%) heterozygous , finally the codon 39 mutations were 2 cases(4%) homozygous and 12 cases(24%) heterozygous. The conclusion is the high incidence of mutations were in IVSI-110 were 7% and the low incidence were codon 39 for beta thalassemia in Bisha, Saudia Arabia by using ARMS technique .
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DOI : 10.36106/ijar
Cite This Article:
Dr. Khaled Ismail Ghaleb, Dr.Mohamed Metwaly Mohamed Characterization of IVS-110,IVS-6 and Codon 39 beta-thalassemia mutations using amplification refractory mutation system (ARMS) technique in Bisha, Saudia Arabia Indian Journal of Applied Research, Vol.IV, Issue. I
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Dr. Khaled Ismail Ghaleb, Dr.Mohamed Metwaly Mohamed Characterization of IVS-110,IVS-6 and Codon 39 beta-thalassemia mutations using amplification refractory mutation system (ARMS) technique in Bisha, Saudia Arabia Indian Journal of Applied Research, Vol.IV, Issue. I
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