Volume : IX, Issue : VIII, August - 2019

Association of serum folic acid and homocysteine with ischemic stroke

Singh P, Diwedi N C, Verma A K, Mathur M, Kirti

Abstract :

Background: Stroke is one of the commonest cause of death in developed countries and is most common cause for the physical disability of a large population. Role of low serum folic acid and hyperhomocysteinemia as risk factor for stroke is not clear. This study was designed to see the association of serum folic acid and hyperhomocysteinemia with ischemic stroke. Aim and objectives: To evaluate the association of serum folic acid level and homocysteine level with ischemic stroke and to measure and compare the serum folic acid level among the cases and control subjects. Material and method: This study was a case–control study which was conducted in the Department Medicine MNL Medical college Prayagraj Uttar Pradesh, India between march 2015 to may 2016 period of 1 year and 2 month A total number of 78 enrolled, 8 were excluded, 70 patients ischemic stroke were selected and 70 control persons were enrolled in this study. All patients of both sexes, aged 18 years and above presented with ischemic stroke, from 0 day to 1 month that was confirmed by CT scan of head/MRI of ain. Blood sample was collected from the cases and the controls analyzed for estimation of serum folic acid, serum homocysteine fasting blood sugar and Fasting lipid profile. Result: The mean ± SD of age of the cases was 58.9 ± 14.47, the control population mean age was 56.6±15.4. The mean (±SD) serum folate level of case and control group was 6.34(± 4.42) and 15.69(± 5.9) respectively. Statistically significant differences was observed between case and control group in level of Serum folate (p<0.05). The study also showed the mean homocysteine level in cases and control was 16.77±2.01 and 7.34±2.53 respectively. Homocysteine level was raised statically significant (p˂0.001) in stroke as compared to controls Conclusion: Low serum folic acid level and hyperhomocysteinemia is significantly associated with increased risk for ischemic stroke.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

ASSOCIATION OF SERUM FOLIC ACID AND HOMOCYSTEINE WITH ISCHEMIC STROKE, Singh P, Diwedi N C, Verma A K, Mathur M, Kirti INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-8 | August-2019

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