Assessment Of Serum Paraoxonase Activity And Malondialdehyde Levels In Nonalcoholic Fatty Liver Disease Patients

Dr. Ramprasad Nagarajrao

Volume : V, Issue : III, March - 2015

Assessment Of Serum Paraoxonase Activity And Malondialdehyde Levels In Nonalcoholic Fatty Liver Disease Patients

Dr. Ramprasad Nagarajrao

Abstract :

Background: Increased oxidative stress and inflammation play a fundamental role in the onset and development of liver diseases. Nonalcoholic fatty liver disease (NAFLD) is an emerging lesion in modern societies, and will become more prevalent in the future. Chemically, oxidative stress occurs as a result of increased level of lipid peroxides and free radical intermediates, as well as decrease in the total antioxidant capacity. Aim: In the present study, our aim was to investigate the lipid peroxidation and Paraoxonase antioxidant enzyme in NAFLD patients in Al– Quwayiyah region of Saudi Arabia. Materials and methods: This study was conducted in Al– Quwayiyah Government General Hospital, Saudi Arabia. We took total 60 patients with NAFLD along with 76 age and sex matched healthy controls. Various biochemical parameters, PON and malondialdehyde were measured and compared. Results: The significantly increased levels of malondialdehyde (MDA) and decreased antioxidant enzyme activity of Paraoxonase (P<0.001) in NAFLD patients when compared to control groups. Conclusion: The study illustrated that in NAFLD patients there is an increased concentration of lipid peroxides may be contribute to decreased levels of antioxidant PON activity. Hence, monitoring of MDA and PON as a routine analysis in clinical biochemistry laboratories.