ASSESMENT OF LIVER FUNCTION TEST IN HIV-HBV CO-INFECTED PATIENTS AT ART PRAYAGRAJ, NORTHERN INDIA

MONICA; BISHT DAKSHINA; MISRA VATSALA; CHAKRABORTY ARINDAM

Volume : IX, Issue : I, January - 2019

ASSESMENT OF LIVER FUNCTION TEST IN HIV-HBV CO-INFECTED PATIENTS AT ART PRAYAGRAJ, NORTHERN INDIA

Monica, Bisht Dakshina, Misra Vatsala, Chakraborty Arindam

Abstract :

OBJECTIVES: 1.To detect the prevalence of hepatitis B virus in HIV positive individuals 2. Impact of HBV– HIV on liver function tests. MATERIAL AND METHODS: A total of 2163 confirmed HIV positive (WHO strategy III) treatment naïve patients enrolled for first time at the ART center were screened for HBsAg by ELISA. LFTs were performed in HIV– HBV coinfected (n=113) and from HIV monoinfected patients(n=100; control group). RESULTS: In HIV–HBV co–infected patients the amount of ALT is increased in (62.8%vs 26%) , AST in (25.6% vs 19%) , ALP in (34.5%vs 17%) ,serum Bilirubin in (53%vs8%) was found to be considerably higher as compared to HIV infected persons only and the difference was statistically significant .Hypoalbuminaemia was seen in 46.9% of HIV– HBV coinfection and only in 16% of HIV patients. CONCLUSION: HIV/HBV Coinfected patients had significantly higher serum bilirubin ,ALT alkaline phosphatase and lower albumin.HIV infected individuals face increased risk of hepatotoxicity from anti–retroviral therapy. So prior to the initiation of antiretroviral treatment (ART) monitoring Individuals with HIV–HBV coinfection should have both the infections completely assessed, in order to decide on the best therapeutic option for both viruses.