Volume : VIII, Issue : VI, June - 2018
APOPTOTIC INDEX– A SIGNIFICANT BIOMARKER IN SPECTRUM OF CERVICAL LESIONS ON PAP SMEAR EXAMINATION
Dr Natasha Makkar
Abstract :
BACKGROUND– Cervical cancer is second most common malignancy. The Pap test, a significant screening tool, has certain subjective limitations. Specific biomarkers are needed to aid diagnosis.Apoptosis is easily discernible in Pap smears in form of karyorrhexis, karyolysis and condensation of chromatin.This study was done to evaluate significance of apoptosis in cervical lesions.
METHODS– The study was conducted on Pap stained smears.Apoptotic index was calculated in each case. The lesions were divided into different categories and mean apoptotic index was calculated for each category. Statistical evaluation was carried out using Student t test.
RESULTS– Total 426 smears,the most common lesion
was inflammatory (43.7%) and least common was invasive carcinoma (4.2%). Invasive tumours had a significantly higher mean apoptotic index.
CONCLUSION– Apoptotic index increases with increasing grade of dysplasia. Apoptotic index is a useful biomarker to evaluate proliferative activity in cervical lesions.
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DOI : 10.36106/ijar
Cite This Article:
DR NATASHA MAKKAR, APOPTOTIC INDEX– A SIGNIFICANT BIOMARKER IN SPECTRUM OF CERVICAL LESIONS ON PAP SMEAR EXAMINATION, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-6 | June-2018
Number of Downloads : 194
DR NATASHA MAKKAR, APOPTOTIC INDEX– A SIGNIFICANT BIOMARKER IN SPECTRUM OF CERVICAL LESIONS ON PAP SMEAR EXAMINATION, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-6 | June-2018
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