Volume : IX, Issue : III, March - 2019

Analysis and Investigatory Profile in the Management and Outcome of Guillian Barre Syndrome

Ganesa Pandian D

Abstract :

Guillain Barre syndrome or acute inflammatory demyelinating polyradiculoneuropathy is an acute onset demyelination of spinal nerve roots and peripheral nerves due to cross reaction between target antigen and myelin, axon or both. Typical clinical features are progressive symmetric muscle weakness associated with absent or depressed deep tendon reflexes. Although GBS has a benign prognosis,7% die and further 16% suffer from residual disability. This study was undertaken to study the clinical and investigatory profile of Guillian Barre symdrome in Rajiv Gandhi government general hospital , Chennai and in attempt to correlate certain clinical and electrophysiological features with prognosis, to identify a poor outcome group in the early stages. Methods: All adult patients (>12yrs) with clinical diagnosis of Guillain Barre syndrome according to Asbury criteria were included. A total of 30 patients were studied, their clinical profile was analyzed and prognosis of these patients in relation to their clinical pattern of progression ,clinical symptoms and signs, cereospinal findings ,nerve conduction study were observed. Patients were analyzed using fisher’s exact probability test with reference to various prognostic factors and their significance determined. Results: Twenty five patients were followed up for prognostic factors in GBS at the end of 3 months, the rest 5 were lost to follow up. Patients were divided into two groups A good outcome group which had disability of grade 3 or less at the end of 3 months and a poor outcome group which had disability grade of greater than 3 at the end of 3 months. Eighteen (782%) patients were found to have a good outcome while 7 (28%) had a poor outcome. Delayed onset of recovery from paralysis, requirement of mechanical ventilator support are significant prognostic factors of outcome in GBS. Conclusion: Delayed onset of recovery from paralysis, requirement of mechanical ventilator support are significant prognostic factors of outcome in GBS. The drawbacks of our study were incomplete follow up due to patient drop out.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

ANALYSIS AND INVESTIGATORY PROFILE IN THE MANAGEMENT AND OUTCOME OF GUILLIAN BARRE SYNDROME, Ganesa pandian D INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-3 | March-2019

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