Volume : VI, Issue : IX, September - 2016

Alloimmunization In Pregnant Women

Mona Abdelrahman, Ahmed Bolad

Abstract :

 Background and Aim: Hemolytic disease of the fetus and newborn (HDN) is a condition in which the lifespan of an infant’s red blood cells (RBCs) is shortened by the action of specific IgG antibodies directed against Rhesus or other blood group antigens on fetal RBCs that are inherited from the father but are not expressed by the mother. The aim of the present study was to provide data on the type and frequency of maternal RBC alloimmunization in pregnant women attending the ante–natal Clinics, King Khalid University Hospital between January 2013 to December 2013 Materials and Methods: A retrospective review of medical records of all pregnant women with RBCs allo–antibodies who were followed and delivered in King Khalid University hospital between January 2013 and December 2013. All samples were tested for blood grouping and screened for irregular antibodies using DiaMed ID Micro Typing system (Gel Test). Results: 4264 samples of pregnant women were tested, 44 samples were found positive with frequencies of 1.03% as follows: anti–D 6 (13.6%),anti–K 6 (13.6 %),anti–E 10 (22.7 %),anti–c 5 (11.4%), anti–E,c 2 (4.5%),anti–D,C 1 (2.3 %), antiFya,Fyb,E 1 (2.3 %), non specific 5 (11.4 %) , anti–E,c,K 1 (1.7%),anti–S 1(1.7%),anti–Leb,Lea,E1 (2.3%), anti–Jka 1 (2.3%) anti–M 1(2.3%),anti–D,C,E 1 (2.3%), anti–,Lea,Lua 1 (2.3%) and anti–Cw 1 (2.3%). Conclusion: Primary prevention by using K–negative, Rh c–, Rh E–, and RhC–compatible red blood cell transfusion for women younger than 45 years may prevent up to 40% of cases of hemolytic disease of the newborn. There was a relationship between abortion and allo–immunization and Increase number of pregnancies gives a chance for alloimmunization to occur. Acknowledgements: Authors would like to extend their thanks to Indian Journal of Applied Research. Special thanks to Al Neelin University (Sudan).

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Mona Abdelrahman, Ahmed Bolad Alloimmunization In Pregnant Women Indian Journal of Applied Research,Volume : 6 | Issue : 9 | September 2016

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