Adverse effects of repeated doses of Ivermectin alone or with the combination of vitamin C on reproductive system of female rabbits

KhawlaBedanAl–Jassim; Ala Al–Deen Hassan Jawad; EmanAboud Al–Masoudi

Volume : V, Issue : IX, September - 2015

Adverse effects of repeated doses of Ivermectin alone or with the combination of vitamin C on reproductive system of female rabbits

Khawlabedanal Jassim, Ala Al Deen Hassan Jawad, Emanaboud Al Masoudi

Abstract :

This study was designed to investigate the effect of repeated administration of Ivermectin alone or with combination of vitamin C on sexual hormones.Besides, an attempt had been done to demonstrate the effect of ivermectinon fertility and pregnancy efficacy of female rabbits. Ninety sixmature female rabbits were used in this study and two experiment had been done. Each experiment were divided into8 groups of equal number(6) as follows: group onewas administered 0.9% Nacl which act as control, Group two, three& fourwere administered (0.5mg/ Kg, 1mg/Kg, 2mg /Kg B.W Ivermectin)respectively, Group fivewas administered 50mg/Kg B.W vitamin C only, Group six, seven & eight were administered 50mg/Kg vitamin C in addition to Ivermectin (0.5mg, 1mg, 2mg respectively).The Ivermectin was given S/C weekly, while vitamin C was given daily P.O. for 8weeks. The results showed significant decrease (P? 0.05) in Estradiol level in 3rd , 4th , 6th , 7th& 8th groups, while progesterone level clarified significant increase (P?0.05) in 5th& 7th groups, the FSH level postulated significant increase (P?0.05) in 4th , 5th& 6th groups, meanwhile, the LH level did not show significant difference in all treated groups as compared with the control group. The results of fertility study revealed adverse effect of ivermectin therapy on fertility and block the pregnancy in all treated group except the fifth group which administered vitamin C only as compared with control group and their effect persistent in second mating in intermediate dose(1mg/Kg Ivermectin) and high dose (2mg/Kg Ivermectin) groups alone and with combination with vitamin C. In conclusion: Ivermectin has adverse effects on reproductive efficacy on female rabbits, as well as, the vitamin C hasnot well emphasized beneficial effects on reproduction.