Volume : IV, Issue : V, May - 2014

ACUTE TOXICITY STUDY OF HERBAL OVULATION INDUCER PRODUCT �ESTROFARM� IN WISTAR RATS

M. M. Gatne, M. J Saxena, K. Ravikanth, A. Thakur

Abstract :

Estrofarm, a polyherbal ovulation inducer product (supplied by m/s Ayurvet Ltd, Baddi, India) was assessed for its acute oral toxicity in wistar rat following OECD Guideline 423. Estrofarm was administered orally in sequential manner to three male and three female rats at the limit dose level of 2000 mg/kg body weight. Animals had free access to standard commercial rat feed, except on the day prior to dosing. Water was provided adlib. The body weights of the rats were recorded prior to dosing, on day 7 and prior to sacrifice on day 14. The animals were observed for signs of convulsions, tremors, circling, depression, excitement and mortality. After the observation period of 14 days, all surviving animals were sacrificed and subjected to complete necropsy to find out any signs of systemic toxicity. All the animals survived by the end of the study without any signs of toxicity. Thus, Estrofarm was found to be safe after oral administration to wistar rat up to a dose of 2000mg/kg body weight.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

M. M. Gatne, M.J Saxena, K. Ravikanth, A. Thakur ACUTE TOXICITY STUDY OF HERBAL OVULATION INDUCER PRODUCT ‘ESTROFARM¥ IN WISTAR RATS Indian Journal of Applied Research, Volume.4, Issue.5, May-2014

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