A Study on the pattern of biopsy-proven renal disease from a tier -2 City in South India

Dr.S.Balamurugan; Dr.Chandrasekar; Dr.S.Kandasamy; Dr.P.Kumaresh

Volume : VIII, Issue : XII, December - 2018

A Study on the pattern of biopsy-proven renal disease from a tier -2 City in South India

Dr. S. Balamurugan, Dr. Chandrasekar, Dr. S. Kandasamy, Dr. P. Kumaresh

Abstract :

Background:. Percutaneous renal biopsy is the mainstay of diagnosis of renal parenchymal disease. This study was done to evaluate the histo–pathological spectrum of (Glomerular Disease)GDs at our Renal centre in two hospitals in Madurai,South Tamilnadu and analyze its clinico–pathological correlation.

Methods: All renal biopsies performed for suspected glomerular diseases at the Two hospitals over a period 5 years from 2012 to 2017 were analyzed (n= 114). Biopsies were performed under ultrasound guidance and processed for light microscopy and immunofluorescence.

Results: Among the total biopsies 114 done, 111 (97.3%)) had biopsy proven GD . The average age of male patients were 37.3 ± 17.62 years and that of females were34.9 +18 years.Male: Female ratio was0.62 :1. 1. The most common clinical syndrome was nephrotic syndrome (41%). Primary Glomerular disease(PGDs) were more common than secondary Glomerular disesase(SGDs) The most common GD presenting as NS was Memanous Nephropathy(MN) (17.5%) followed by Minimal Change disease(MCD),Focal segmental Glomerulosclerosis(FSGS) and MPGN. Lupus nephritis (LN) (16.6%) was the commonest SGD, followed by Diabetic Nephropathy/Nondiabetic renal disease(DN/ NDRD) . Crescentic GN was seen in4.4% cases majority presenting as RPGN. IgAN comprised 7% GNs. Amyloidosis was diagnosed in 0.87% of biopsies.

Conclusion: Histo–pathological examination with LM and IF techniques and correlation with clinical, biochemical and serological markers as done in this study, have proved useful for the accurate diagnosis of glomerular diseases. It also provides important epidemiological information towards setting up a renal biopsy registry.