Volume : III, Issue : I, January - 2013

A study on Statin use and Hepato–damaging effects

Dr Seema Mishra

Abstract :

 The beneficial role of Statins in primary and secondary prevention of coronary heart disease has resulted in their frequent use in clinical practice. However, safety concerns, especially regarding hepatotoxicity, have driven multiple trials, which have demonstrated the low or moderate  incidence of statin–related hepatic adverse effects. The most commonly reported hepatic adverse effect is the phenomenon known as transaminitis, in which liver enzyme levels are elevated in the absence of proven hepatotoxicity. This class effect is usually asymptomatic, reversible, and dose–related. However, the increasing incidence of chronic liver diseases, including nonalcoholic fatty liver disease and hepatitis C, has created a new challenge when initiating Statin treatment in patients with high cardiovascular risk. These diseases result in abnormally high liver biochemistry values, discouraging Statin use by clinicians, fostering treatment discontinuation, and leaving a large number of at–risk patients untreated. In this study the CVD patients with and without history of liver disease were studied, who are Statin users. This review supports the use of Statin treatment in patients with high cardiovascular risk whose elevated aminotransferase levels should be closely monitored ,while taking this medicine

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr Seema Mishra, A study on Statin use and Hepato-damaging effects, Indian Journal of Applied Research, Vol.III, Issue.I January 2013

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