A Study on Evaluation of Efficacy of Treatment of Typhoid Fever with Ceftriaxone and Chloramphenicol in a Tertiary Care Centre in Eastern Bihar.

Dr Ravi Anand; Dr Hemshankar Sharma

Volume : IX, Issue : III, March - 2019

A Study on Evaluation of Efficacy of Treatment of Typhoid Fever with Ceftriaxone and Chloramphenicol in a Tertiary Care Centre in Eastern Bihar.

Dr Ravi Anand, Dr Hemshankar Sharma

Abstract :

Aims and Objectives: To evaluate and compare the efficacy of ceftriaxone and chloramphenicol in adults. Materials & Methods: We assessed a total of 100 patients with enteric fever who reported to the department of Medicine of Jawahar Lal Nehru Medical College and Hospital, Bhagalpur, Bihar from December 2016 to November 2017. Patients with such clinical presentations as blood and/or stool cultures that tested positive for S. typhi were included. All the patients were randomly divided into two study groups; group A and group B. Group A included subjects who were treated with ceftriaxone for 7 days, while group B included subjects who were treated with chloramphenicol for 14 days. Complete recording of all the demographic and biochemical parameters of the patients was done regularly. The effects of therapy were assessed both clinically and bacteriologically. All the results were compiled and analysed by SPSS software. Results: Both the study groups consisted of 50 patients each. Mean age of the subjects of group A and Group B were 19.5 and 22.1 years respectively. Mean duration of fever of subjects of group A and group B were 7 and 8 days respectively. Nonsignificant result were obtained while compå the efficacy of both the antibiotic therapies (p value > 0.05). Conclusion: For treating enteric fever, ceftriaxone will be useful for patients in whom a shorter course treatment therapy is preferred.