Volume : VII, Issue : I, January - 2017
A STUDY ON “ENDOTHELIAL DYSFUNCTION IN PRE DIABETES AS EVIDENCED BY FLOW MEDIATED VASODILATATION”
Dr. V. Shiva Prasad, Dr. D. Sridhar
Abstract :
BACKGROUND
Endothelial dysfunction is an early event in atherosclerosis and is known to appear long before the formation of structural atherosclerotic changes. Assessment of endothelial function, thus, can provide valuable insight into pre–intrusive phase of atherosclerosis and can be used as an early marker of future Atherosclerotic disease .Flow mediated dilation (FMD) is known to depend on ability of the endothelium to release NO in response to shear stress and can be used reliably as an estimate of endothelial function in various disease states. Pre diabetic state characterized by impaired glucose tolerance leads to endothelial dysfunction through insulin resistance state ,implicating the necessicity for identification of endothelial dysfunction at an early stage and treat it.
AIM OF STUDY: To study the occurrence of endothelial dysfunction in pre diabetics and to correlate various risk factor in pre diabetics with endothelial dysfunction.
METHODOLOGY:
Endothelial function was assessed non–invasively by high resolution Duplex Doppler Ultrasound of Brachial Artery in fifty pre diabetics cases who were included based on impaired fasting glucose (IFG). FMD was calculated as percentage increase in achial artery diameter in response to increase in achial artery flow.
RESULTS
In this study endothelial dysfunction is observed in 3(6%) out of 50 pre diabetics ,out of them 2
(4.65%) being male and 1(14.28% )being female. Among these pre diabetic individuals
endothelial dysfunction occurred in individuals who have greater BMI (p<0.017%); HbA1c >6% (p<0.001) and males with greater waist /hip ratio (p<0.001).
CONCLUSION
Endothelial dysfunction as assessed by FMD is also documented in pre diabetic state . Its
occurrence is in correlation with risk factors such as obesity ,higher HbA1c at time of diagnosis.
Keywords :
CHD ? Coronary Heart Disease DM ? Diabetes Mellitus ED ? Endothelial Dysfunction EDRF ? Endothelin Derived Releasing Factor FBS ? Fasting Blood Sugar FMD ? Flow Mediated Dilation NO ? Nitric Oxide
Article:
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DOI : 10.36106/ijar
Cite This Article:
Dr. V. Shiva Prasad, Dr. D. Sridhar, A STUDY ON ENDOTHELIAL DYSFUNCTION IN PRE DIABETES AS EVIDENCED BY FLOW MEDIATED VASODILATATION, Indian Journal of Applied Research,Volume : 7 | Issue : 1 | JANUARY 2017
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Dr. V. Shiva Prasad, Dr. D. Sridhar, A STUDY ON ENDOTHELIAL DYSFUNCTION IN PRE DIABETES AS EVIDENCED BY FLOW MEDIATED VASODILATATION, Indian Journal of Applied Research,Volume : 7 | Issue : 1 | JANUARY 2017
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