A SOLVENT-FREE GREEN ROUTE TO FLUORINATED ISOXAZOLIDINES AND THEIR BIOLOGICAL EVALUATION AS POTENT ALDOSE REDUCTASE INHIBITORS

Manpreet Kaur; Kulvir Kaur; Baldev Singh

Volume : IX, Issue : III, March - 2019

A SOLVENT-FREE GREEN ROUTE TO FLUORINATED ISOXAZOLIDINES AND THEIR BIOLOGICAL EVALUATION AS POTENT ALDOSE REDUCTASE INHIBITORS

Manpreet Kaur, Kulvir Kaur, Baldev Singh

Abstract :

A simple and environmentally benign method has been developed for the synthesis of fluorinated isoxazolidine derivatives from 1,3–dipolar cycloaddition reactions of azomethine N–oxides and fluoro substituted maleimide on montmorillonite K–10 clay as solid acid catalysts by microwave under solvent–free conditions and evaluate these compounds for their advanced glycation end (AGE) product formation inhibitory activity.