A RETROSPECTIVE CLINICOPATHOLOGICAL STUDY OF SINONASAL ADENOID CYSTIC CARCINOMA IN A TERTIARY CARE HOSPITAL OF CENTRAL UTTAR PRADESH

Rashmi Chaturvedi; Chitransha Srivastav

Volume : IX, Issue : III, March - 2019

A RETROSPECTIVE CLINICOPATHOLOGICAL STUDY OF SINONASAL ADENOID CYSTIC CARCINOMA IN A TERTIARY CARE HOSPITAL OF CENTRAL UTTAR PRADESH

Rashmi Chaturvedi, Chitransha Srivastav

Abstract :

INTRODUCTION: Adenoid cystic carcinoma (ACC) of the sinonasal tract is a rare cancer that accounts for 10% of all malignancies at this site. The objective of the current study was to evaluate prognostic factors, treatment outcomes, recurrence patterns, and survival rates for sinonasal adenoid cystic carcinoma. METHODS: A retrospective chart review was performed at a tertiary referral center between 2010 and 2015, 15 patients were evaluated for ACC of the sinonasal tract at a single institution. demographics, presentation, anatomic site, tumor, lymph node, metastasis (TNM) classification, pathology, treatment, recurrences, and survival were evaluated. RESULTS: The median age of patients was 52 years, and the mean follow–up was 36 months. The maxillary sinus (46.6%) and the nasal cavity (33.3%) were the most common primary tumor sites. The majority of patients presented with T3/T4 (73.3.7%) without any nodal and distant metastasis. All the patients underwent surgery and received postoperative radiation as treatment for their primary disease. The local recurrence rate was 40%. CONCLUSION–ACC of the sinonasal tract is a rare tumor. Poor prognostic factors that affect survival include tumor site, extent of invasion, stage, histopathologic type and grade. The current data suggested that surgical resection with postoperative radiation therapy offers durable local control and compares favorably with historic data. Since local recurrences develop in a significant percentage of patients, therefore, the ideal treatment paradigm has yet to be defined. However survival from this disease exceeds that of other sinonasal malignancies.