A COMPARATIVE STUDY OF ROCURONIUM PRIMING, MAGNESIUM PRE-TREATMENT AND THEIR COMBINATION IN NEUROMUSCULAR BLOCKING CHARACTERESTICS AND QUALITY OF TRACHEAL INTUBATING CONDITIONS.

Dr. S. Saiprabha; Dr T. N .Jithin

Volume : VII, Issue : XI, November - 2017

A COMPARATIVE STUDY OF ROCURONIUM PRIMING, MAGNESIUM PRE-TREATMENT AND THEIR COMBINATION IN NEUROMUSCULAR BLOCKING CHARACTERESTICS AND QUALITY OF TRACHEAL INTUBATING CONDITIONS.

Dr. S. Saiprabha, Dr T. N . Jithin

Abstract :

Background and Aim : Priming principle produces a relatively rapid and profound neuromuscular blockade to ensure suitable conditions for endotracheal intubation. This study was done to compare Rocuronium priming , Magnesium pre–treatment and their combination to assess the characteristics and quality of tracheal intubating condition.

Methods :This double– blinded ,randomised controlled prospective study was carried out at a tertiary health care hospital on patients undergoing surgical procedure under general anaesthesia.60 ASA I or II patients were randomly allocated into 4 groups (n=15) as control (group R) , Prime (group RP), Magnesium (group RM), Magnesium and Prime (group RPM). The hemodynamic parameter and intubating conditions were studied and statistically analysed using chi–square test and one–way ANOVA test.

Result : Magnesium sulphate pre–treatment and priming with Rocuronium provided faster onset of NM blockade (51.6 sec in group RPM when compared to 139.6 sec in group R ) with excellent intubating condition.

Conclusion : Pre–treatment with both magnesium sulphate and a priming dose of Rocuronium provided faster onset of neuromuscular blockade and superior intubating conditions for rapid sequence intubation ,compared with magnesium sulphate or priming alone.