Vitamin-Status in Patients scheduled for Cardiac Surgery. A Prospective Single Centre Analysis

Nestoras Papadopoulos; Irene Gleske; Anton Moritz

Volume : V, Issue : IX, September - 2016

Vitamin-Status in Patients scheduled for Cardiac Surgery. A Prospective Single Centre Analysis

Nestoras Papadopoulos, Irene Gleske, Anton Moritz

Abstract :

BACKROUND: This prospective single center study was designed to evaluate the prevalence of deficiency and postoperative level-course of vitaminD (25-hydroxyvitamin D=25(OH)D), E, C and A in cardiosurgical patients. METHODS: Hundred high-risk patients scheduled for elective cardiac surgery were enrolled in this study between January 2010 and March 2013. Fasting serum samples were taken in five different perioperative time-points. RESULTS: Fifty-nine percent of the patient had moderate to sever 25(OH)D deficiency (serum levels<29.9nmol/L), whereas the majority of the patients were presented with sufficient preoperative vitamin E (99%), C (88%) and A (98%) levels. Circulating levels of 25(OH)D below 29.9 nmol/L prior to surgery were associated with an increased in-hospital-mortality (OR=2.78; 95%CI=1.25-3.89, p:0.021) and prolonged intensive care unit stay (p:0.047). CONCLUSION: Moderate to severe 25(OH)D deficiency is prevalent in high-risk patients scheduled for cardiac surgical and is associated with an increased in-hospital mortality and prolonged intensive care unit stay. Abstract Word Count: 150