UTILITY OF PLASMA THROMBOPLASTIN CELL BLOCK TECHNIQUE IN CASES OF PLUERAL AND PERITONEAL EFFUSION SUSPECTED FOR MALIGNANCY

Dr. Savitri Shukla; Prerena

Volume : VI, Issue : IV, April - 2017

UTILITY OF PLASMA THROMBOPLASTIN CELL BLOCK TECHNIQUE IN CASES OF PLUERAL AND PERITONEAL EFFUSION SUSPECTED FOR MALIGNANCY

Dr. Savitri Shukla, Prerena

Abstract :

Background- Cell block preparation act as a usefull adjunct on a smear cytology for diagnosis of pleural and peritoneal effusion by using plasma thromboplastin cell block technique. Diagnostic problem arises in day to day practice to differentiate reactive mesothelial cells and malignant cells by conventional smears method, cell block technique is easy required less time and showing improved cytomorphological features and helps to differentiate reactive mesothelial cells and malignant cells and thereby increases diagnostic efficacy and additional benefits when used with routine cytology. Material & method- Total 168 cases are studied out of which majority of cases were reactive (n=154, 91.7%). Only 14 cases (8.3%) were malignant. Among the reactive effusions, the commonest cause was tuberculosis (n=98, 58.3%). Result- There is statistically significant increase in the frequency of malignant cells found on cell block technique as compared to conventional smear which is n=14 versus n=8. As 6 cases which were diagnosed as suspicious of malignancy on conventional smear were diagnosed as malignant in the sections of cell block. Conclusion-Increases in Cellularity, better architecture display and morphological preservation in cell block technique aids in diagnosing the hidden cases of malignancy so it should be used as an adjunct to conventional smears to aid and improve the diagnosis in serous fluid cytology