Volume : IV, Issue : VIII, August - 2015

Trehalose – current applications in ophthalmology and future perspectives

Jitka Cejkova, Cestmir Cejka

Abstract :

Trehalose, a disaccharide of glucose, is a stress response factor synthetized by many organismims when cells are exposed to stressful conditions, including dehydration, heat, oxidation, hypoxia or even anoxia. Trehalose is not synthesized by mammalian cells; however, it has been recently demonstrated to have a number of unique properties that point to its utility in humans. Trehalose enables wound healing by protecting cells, especially cell memanes, from oxidative injury and dessication. In the injured cornea trehalose suppresses inflammation, scar formation and corneal neovascularization. In dry eye disease trehalose decreases cell apoptosis a reduces inflammatory and proteolytic activity at the ocular surface. Trehalose may prevent neurodegenerative disorders by stabilizing proteins and promoting autophagy. In animal models of neurodegenerative disorders trehalose decreases levels of toxic protein aggregates, increases autophagy and improves clinical symptoms and survival. The low toxicity of this bioactive sugar allows its administration in humans for extended periods and enables its use in various disease states.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Jitka Cejkova, Cestmir Cejka Trehalose – Current Applications in Ophthalmology And Future Perspectives Global Journal For Research Analysis, Vol: 4, Issue: 8 August 2015

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